Precocious unicorns.

AI in clinical recruitment.

Gen Z lightweights.

 

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March 20, 2025

The Wiz Kid

Hi there, 

 

Here is this week’s Hot or Not.

 

Hot: Google x Wiz

 

Google just made its biggest acquisition ever.

 

Its $33B acquisition of cloud security startup Wiz is 2.4x larger than its second-largest purchase (Motorola Mobility in 2012). 

 

The deal also marks the largest cybersecurity exit in history, surpassing Splunk’s $28B sale to Cisco.

 

Google’s M&A strategy has evolved from adtech (YouTube, DoubleClick) to mobile (Nest, Motorola) to cloud (Mandiant, Looker). The Wiz deal cements its shift toward cloud security as it battles Microsoft and AWS.

 

All told, Google has spent nearly $66B on its top 10 acquisitions — with half of that going to Wiz. 

 

See how Wiz stacks up against Google’s other biggest acquisitions here.

GoogleMegaAcqusitions-032025 2

Not: Later-stage unicorns

 

As the VC market prioritizes early-stage bets, it’s getting harder for late-stage companies to raise at billion-dollar valuations. 

 

Instead, early- and mid-stage players are dominating new unicorn births. 

 

Since 2023, 68% of new unicorns reached billion-dollar valuations at Series C or earlier — up from 48% between 2013 and 2022. 

 

Three forces are driving bigger bets, sooner:

  • AI hype is pulling valuations forward. Nearly half of 2024’s new unicorns were AI startups, with 74% of AI deals happening early-stage.
  • FOMO is driving early-stage bidding wars. Investors are locking in category leaders early, bypassing traditional growth rounds in a tighter funding market.
  • More dry powder, fewer deals. With 2024 venture dealmaking at an 8-year low, capital is flowing into earlier-stage bets.

The result is a 2-speed market where top startups are fast-tracking to unicorn status, while late-stage companies face a tougher road to high valuations.

 

For a deeper dive into the trends reshaping unicorn creation, check out this breakdown from our new Head of Insights, Jason Saltzman.

unicornbirthsgif

Hot: AI for clinical trials

 

Clinical trials cost $55M on average and can take more than a decade to complete.

 

Even so, over 90% of drugs fail at the clinical stage.

 

Pharma and tech giants are betting on AI to de-risk the clinical development pipeline, from improving protocol design to analyzing larger and more complex datasets than ever before.

 

One standout application is patient recruitment, where AI can perform the initial screening process and match patients to clinical trials via EHR analysis.

 

Four of the 10 largest deals in AI clinical development since 2023 went to patient recruitment platforms, and just this week, Tempus acquired Deep 6 AI, citing the latter’s coverage of 30M+ patients.

 

Dive into AI’s 8 applications in clinical development in this report.

    AI-in-Clinical-Development_Overview-1

    Not: Coca-Cola M&A

     

    PepsiCo announced it’s acquiring Poppi for $1.95B, its fourth acquisition in six months.

     

    With healthy soda sales up 60% year-over-year, Pepsi is securing a brand with viral momentum and a strong D2C strategy.

     

    Coca-Cola, meanwhile, is sticking to product launches, opting to develop Simply Pop instead of making a deal.

     

    Coke once led in strategic acquisitions, including buying up BodyArmor and Topo Chico, but its M&A activity has waned.

     

    CBI customers can see every M&A deal done by the beverage giants here.

    Screenshot 2025-03-20 at 4.48.43 PM

    The +1

    money spent on alcohol by generation

    Bottoms up. Not sure it’s a fair comparison when the youngest Gen Zers are still tweens. Garbage in, garbage out. 

     

    I love you.

     

    Anand

    @asanwal 

    Co-Founder & Exec Chair

     

    P.S. This week’s newsletter features insights from CB Insights' new Head of Insights, Jason Saltzman. Follow him on LinkedIn for more analysis and the latest CB Insights data — plus plenty of pretty charts.

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